期刊
FEBS JOURNAL
卷 277, 期 14, 页码 2912-2920出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1742-4658.2010.07716.x
关键词
metallothionein (MT); mutation; neuronal growth-inhibitory factor (GIF); structure-function relationship
资金
- National Natural Science Foundation of China
Neuronal growth-inhibitory factor (GIF), also named metallothionein-3, inhibits the outgrowth of neuronal cells. Recent studies on the structure of human GIF, carried out using NMR and molecular dynamics simulation techniques, have been summarized. By studying a series of protein-engineered mutants of GIF, we showed that the bioactivity of GIF is modulated by multiple factors, including the unique TCPCP motif-induced characteristic conformation, the solvent accessibility and dynamics of the metal-thiolate cluster, and the domain-domain interactions.
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