相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth
Julia Saermann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
Yanping Li et al.
NATURE NEUROSCIENCE (2009)
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase (vol 27, pg 2239, 2008)
Katja Gotthardt et al.
EMBO JOURNAL (2008)
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
Yuzuru Imai et al.
EMBO JOURNAL (2008)
Intramolecular Activation Mechanism of theDictyosteliumLRRK2 Homolog Roco Protein GbpC
Wouter N. van Egmond et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
Michelle Gray et al.
JOURNAL OF NEUROSCIENCE (2008)
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
Lizhen Wang et al.
JOURNAL OF NEUROSCIENCE (2008)
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
Payal N. Gandhi et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2008)
Lrrk2 and α-synuclein are co-regulated in rodent striatum
Marie Westerlund et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2008)
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Daniel G. Healy et al.
LANCET NEUROLOGY (2008)
Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
Danling Wang et al.
MOLECULAR NEURODEGENERATION (2008)
Investigating convergent actions of genes linked to familial Parkinson's disease
Benjamin Wolozin et al.
NEURODEGENERATIVE DISEASES (2008)
A Drosophila model for LRRK2-linked parkinsonism
Zhaohui Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Update on the functional biology of Lrrk2
Heather Melrose
FUTURE NEUROLOGY (2008)
Dynamic and redundant regulation of LRRK2 and LRRK1 expression
Saskia Biskup et al.
BMC NEUROSCIENCE (2007)
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
Luxuan Guo et al.
EXPERIMENTAL CELL RESEARCH (2007)
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
H. L. Melrose et al.
NEUROSCIENCE (2007)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Mahaboobi Jaleel et al.
BIOCHEMICAL JOURNAL (2007)
Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
Sung Bae Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain
Shinji Higashi et al.
BRAIN RESEARCH (2007)
LRK-1, a C-elegans PARK8-Related kinase, regulates axonal-dendritic polarity of SV proteins
Aisa Sakaguchi-Nakashima et al.
CURRENT BIOLOGY (2007)
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
Genta Ito et al.
BIOCHEMISTRY (2007)
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
Andrew B. West et al.
HUMAN MOLECULAR GENETICS (2007)
Identification of potential protein interactors of Lrrk2
Justus C. Daechsel et al.
PARKINSONISM & RELATED DISORDERS (2007)
The Parkinson disease gene LRRK2:: Evolutionary and structural insights
Ignacio Marin
MOLECULAR BIOLOGY AND EVOLUTION (2006)
The familial parkinsonism gene LRRK2 regulates neurite process morphology
David MacLeod et al.
NEURON (2006)
Kinase activity of mutant LRRK2 mediates neuronal toxicity
Wanli W. Smith et al.
NATURE NEUROSCIENCE (2006)
Distribution of PINK1 and LRRK2 in rat and mouse brain
Jean-Marc Taymans et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Elisa Greggio et al.
NEUROBIOLOGY OF DISEASE (2006)
LRRK2 expression linked to dopamine-innervated areas
D Galter et al.
ANNALS OF NEUROLOGY (2006)
LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain
J Simón-Sánchez et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews
LJ Ozelius et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
CJ Gloeckner et al.
HUMAN MOLECULAR GENETICS (2006)
Anatomical localization of Leucine-rich repeat kinase 2 in mouse brain
H Melrose et al.
NEUROSCIENCE (2006)
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
WW Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium
L Bosgraaf et al.
JOURNAL OF CELL SCIENCE (2005)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Roc, a Ras/GTPase domain in complex proteins
L Bosgraaf et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2003)
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
SC Gong et al.
NATURE (2003)
The identification of Pats1, a novel gene locus required for cytokinesis in Dictyostelium discoideum
JC Abysalh et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium
L Bosgraaf et al.
EMBO JOURNAL (2002)
Bac to the future: The use of bac transgenic mice for neuroscience research
N Heintz
NATURE REVIEWS NEUROSCIENCE (2001)