期刊
FEBS JOURNAL
卷 276, 期 10, 页码 2669-2685出版社
WILEY
DOI: 10.1111/j.1742-4658.2009.06986.x
关键词
actin dynamics; actin-binding protein; chromatin remodeling; gene regulation; muscle-specific gene; nuclear actin; nuclear receptor; ribonucleoprotein; RNA polymerases; transcription complex
资金
- Program for Major State Basic Research Development Program of China [2008CB517402]
- National Natural Science Foundation of the People's Republic of China [30770787, 30670845, 30871272]
- New Century Excellent Talents in University [NCET-05-0261]
- Key Project of Chinese Ministry of Education [206016]
- Hebei Natural Science Foundation of the People's Republic of China [C2008001049]
- NIH, National Institute on Aging
- NATIONAL INSTITUTE ON AGING [ZIAAG000892] Funding Source: NIH RePORTER
Nuclear actin is involoved in the transcription of all three RNA polymerases, in chromatin remodeling and in the formation of heterogeneous nuclear ribonucleoprotein complexes, as well as in recruitment of the histone modifier to the active gene. In addition, actin-binding proteins (ABPs) control actin nucleation, bundling, filament capping, fragmentation and monomer availability in the cytoplasm. In recent years, more and more attention has focused on the role of actin and ABPs in the modulation of the subcellular localization of transcriptional regulators. This review focuses on recent developments in the study of transcription and transcriptional regulation by nuclear actin, and the regulation of muscle-specific gene expression, nuclear receptor and transcription complexes by ABPs. Among the ABPs, striated muscle activator of Rho signaling and actin-binding LIM protein regulate actin dynamics and serum response factor-dependent muscle-specific gene expression. Functionally and structurally unrelated cytoplasmic ABPs interact cooperatively with nuclear receptor and regulate its transactivation. Furthermore, ABPs also participate in the formation of transcription complexes.
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