期刊
FEBS JOURNAL
卷 276, 期 7, 页码 1800-1816出版社
WILEY
DOI: 10.1111/j.1742-4658.2009.06927.x
关键词
calcium; calcium store; CICR; compartmentalized; cyclic ADP-ribose; inositol trisphosphate receptor; microdomains; nicotinamide adenine dinucleotide phosphate; organelle; ryanodine intracellular receptor
资金
- North West Cancer Research Fund
Ca2+ regulates a multitude of cellular processes and does so by partitioning its actions in space and time. In this review, we discuss how Ca2+ responses are constructed from small quantal (elementary) events that have the potential to propagate to produce large pan-cellular responses. We review how Ca2+ is compartmentalized both physically and functionally, and describe how each organelle has its own distinct Ca2+-handling properties. We explain how coordination of the movement of Ca2+ between organelles is used to shape and hone Ca2+ signals. Finally, we provide a number of specific examples of where compartmentation and localization of Ca2+ are crucial to cell function.
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