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Erkang Fei et al.
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Sovan Sarkar et al.
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Mei Li et al.
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Y. Kouroku et al.
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Christian Haass et al.
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David C. Rubinsztein et al.
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Peter T. Lansbury et al.
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Ken Inoki et al.
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Taichi Hara et al.
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Masaaki Komatsu et al.
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Mamoru Shibata et al.
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Sovan Sarkar et al.
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Z Berger et al.
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Growing roles for the mTOR pathway
DD Sarbassov et al.
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Z Berger et al.
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Lithium induces autophagy by inhibiting inositol monophosphatase
S Sarkar et al.
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SQ Luo et al.
JOURNAL OF CELL BIOLOGY (2005)
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
M Tanaka et al.
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QF Chen et al.
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CA Ross et al.
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Autophagosome-like vacuole formation in Huntington's disease lymphoblasts
E Nagata et al.
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B Ravikumar et al.
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M Arrasate et al.
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NI Wood et al.
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JL Webb et al.
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CJ Phiel et al.
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HK Chen et al.
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ES Emamian et al.
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B Ravikumar et al.
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Autophagosome formation in mammalian cells
N Mizushima et al.
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J Carmichael et al.
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S Humbert et al.
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B Ravikumar et al.
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Lessons from animal models of Huntington's disease
DC Rubinsztein
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Å Petersén et al.
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N Mizushima et al.
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Molecular targets of lithium action
CJ Phiel et al.
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Y Kabeya et al.
EMBO JOURNAL (2000)
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A Petiot et al.
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