期刊
FEBS JOURNAL
卷 275, 期 17, 页码 4263-4270出版社
WILEY
DOI: 10.1111/j.1742-4658.2008.06562.x
关键词
autophagy; Huntington's disease; lithium; mTOR; polyglutamine; rapamycin
资金
- Medical Research Council [G0600194] Funding Source: researchfish
- MRC [G0600194] Funding Source: UKRI
- Medical Research Council [G0600194, G0600194(77639)] Funding Source: Medline
- Wellcome Trust [064354] Funding Source: Medline
Autophagy is a nonspecific bulk degradation pathway for long-lived cytoplasmic proteins, protein complexes, or damaged organelles. This process is also a major degradation pathway for many aggregate-prone, disease-causing proteins associated with neurodegenerative disorders, such as mutant huntingtin in Huntington's disease. In this review, we discuss factors regulating the degradation of mutant huntingtin by autophagy. We also report the growing list of new drugs/pathways that upregulate autophagy to enhance the clearance of this mutant protein, as autophagy upregulation may be a tractable strategy for the treatment of Huntington's disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据