期刊
FASEB JOURNAL
卷 27, 期 7, 页码 2600-2610出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.12-222844
关键词
C-26; respiratory muscles; muscle function; single fiber; limb muscle
资金
- Bankhead Coley Cancer Research Program [09BN-09]
- U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01AR060209]
- U.S. National Institute of Neurological Disorders and Stroke [R01 NS080180]
- U.S. National Heart, Lung, and Blood Institute [R01HL087839, R00HL098453]
Cancer cachexia is characterized by a continuous loss of locomotor skeletal muscle mass, which causes profound muscle weakness. If this atrophy and weakness also occurs in diaphragm muscle, it could lead to respiratory failure, which is a major cause of death in patients with cancer. Thus, the purpose of the current study was to determine whether colon-26 (C-26) cancer cachexia causes diaphragm muscle fiber atrophy and weakness and compromises ventilation. All diaphragm muscle fiber types were significantly atrophied in C-26 mice compared to controls, and the atrophy-related genes, atrogin-1 and MuRF1, significantly increased. Maximum isometric specific force of diaphragm strips, absolute maximal calcium activated force, and maximal specific calcium-activated force of permeabilized diaphragm fibers were all significantly decreased in C-26 mice compared to controls. Further, isotonic contractile properties of the diaphragm were affected to an even greater extent than isometric function. Ventilation measurements demonstrated that C-26 mice have a significantly lower tidal volume compared to controls under basal conditions and, unlike control mice, an inability to increase breathing frequency, tidal volume, and, thus, minute ventilation in response to a respiratory challenge. These data demonstrate that C-26 cancer cachexia causes profound respiratory muscle atrophy and weakness and ventilatory dysfunction.Roberts, B. M., Ahn, B., Smuder, A. J., Al-Rajhi, M., Gill, L. C., Beharry, A. W., Powers, S. K., Fuller, D. D., Ferreira, L. F., Judge, A. R. Diaphragm and ventilatory dysfunction during cancer cachexia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据