相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Statins inhibit the dimerization of β-secretase via both isoprenoid-and cholesterol-mediated mechanisms
Richard B. Parsons et al.
BIOCHEMICAL JOURNAL (2006)
Brain cholesterol turnover required for geranylgeraniol production and learning in mice
TJ Kotti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Statins cause intracellular accumulation of amyloid precursor protein, β-secretase-cleaved fragments, and amyloid β-peptide via an isoprenoid-dependent mechanism
SL Cole et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Association of active γ-secretase complex with lipid rafts
Y Urano et al.
JOURNAL OF LIPID RESEARCH (2005)
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production
T Kukar et al.
NATURE MEDICINE (2005)
ApoAl deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-β pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis
AM Fagan et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Cholesterol and Alzheimer's disease: Clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors
K Sambamurti et al.
CURRENT DRUG TARGETS (2004)
Atorvastatin-induced activation of Alzheimer's α secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding
S Parvathy et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Association between statin use and Alzheimer's disease
E Zamrini et al.
NEUROEPIDEMIOLOGY (2004)
Association of γ-secretase with lipid rafts in post-golgi and endosome membranes
KS Vetrivel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
APP intracellular domain is increased and soluble Aβ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease
AJ George et al.
NEUROBIOLOGY OF DISEASE (2004)
The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease
B Hutter-Paier et al.
NEURON (2004)
γ-secretase activity is present in rafts but is not cholesterol-dependent
S Wada et al.
BIOCHEMISTRY (2003)
Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Aβ42 by inhibiting Rho
Y Zhou et al.
SCIENCE (2003)
Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis
SE Ownby et al.
LIPIDS (2003)
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
R Ehehalt et al.
JOURNAL OF CELL BIOLOGY (2003)
Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein
M Sjogren et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2003)
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease:: A 26-week randomized, placebo-controlled, double-blind trial
M Simons et al.
ANNALS OF NEUROLOGY (2002)
Cholesterol and Alzheimer's disease
B Wolozin
BIOCHEMICAL SOCIETY TRANSACTIONS (2002)
Statin therapy for Alzheimer's disease - Will it work?
SS Petanceska et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
S Wahrle et al.
NEUROBIOLOGY OF DISEASE (2002)
A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease
LM Refolo et al.
NEUROBIOLOGY OF DISEASE (2001)
Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid β-peptide
L Puglielli et al.
NATURE CELL BIOLOGY (2001)
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
K Fassbender et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
A novel γ-secretase assay based on detection of the putative C-terminal fragment-γ of amyloid β protein precursor
I Pinnix et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
B Wolozin et al.
ARCHIVES OF NEUROLOGY (2000)
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
LM Refolo et al.
NEUROBIOLOGY OF DISEASE (2000)