期刊
FARADAY DISCUSSIONS
卷 152, 期 -, 页码 33-42出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1fd00024a
关键词
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资金
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering [DE-FG02-04ER46141]
- National Science Foundation (NSF) Center for Hierarchical Manufacturing at the University of Massachusetts (NSEC) [DMI-0531171]
- NIH [GM077173, AI073425]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI073425] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM077173] Funding Source: NIH RePORTER
Nanoparticle-based sensor arrays have been used to distinguish a wide range of biomolecular targets through pattern recognition. Such biosensors require selective receptors that generate a unique response pattern for each analyte. The tunable surface properties of gold nanoparticles make these systems excellent candidates for the recognition process. Likewise, the metallic core makes these particles fluorescence superquenchers, facilitating transduction of the binding event. In this report we analyze the role of gold nanoparticles as receptors in differentiating a diversity of important human proteins, and the role of the polymer/biopolymer fluorescent probes for transducing the binding event. A structure-activity relationship analysis of both the probes and the nanoparticles is presented, providing direction for the engineering of future sensor systems.
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