期刊
FAMILIAL CANCER
卷 7, 期 4, 页码 287-292出版社
SPRINGER
DOI: 10.1007/s10689-008-9190-z
关键词
Colorectal cancer; Colon cancer; Rectal cancer; Family history; Women; Survival
资金
- AHRQ HHS [5T32HS013853] Funding Source: Medline
- NCI NIH HHS [CA14520, CA47147] Funding Source: Medline
Purpose Family history of colorectal cancer may be a phenotype for numerous genetic mutations which increase colorectal cancer risk and may affect survival after diagnosis. We examined the relationship between self-reported first-degree family history of colorectal cancer and survival. Methods We identified female Wisconsin residents ages 20-74 with a new diagnosis of invasive colorectal cancer from two population-based case-control studies; 1,469 women were interviewed. Follow-up averaged 7.9 years. We performed multivariable Cox proportional hazards regressions to calculate adjusted hazard rate ratios [HR] and corresponding 95% confidence intervals [95% CI] for risk of death by family history. Results Of 1,391 cases with available first-degree family history, 481 were deceased, 268 due to colorectal cancer. In multivariable analyses, cases with any family history (N = 262) had a statistically non-significant lower risk of death (HR 0.86, 95% CI 0.62, 1.20) compared to no family history (N = 1,129). Cases with two or more affected family members (N = 46) showed significantly lower risk of death when compared to women with no family history (HR 0.34, 95% CI 0.13, 0.92). Conclusions Although individuals with a colorectal cancer family history are diagnosed with the disease more often than the general population, these data suggest that survival from colorectal cancer may not be worse.
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