期刊
FAMILIAL CANCER
卷 8, 期 2, 页码 167-171出版社
SPRINGER
DOI: 10.1007/s10689-008-9222-8
关键词
Androgen deprivation; Colon cancer; Monozygotic twins; Prostate cancer; Wnt signalling
资金
- Sassella Stiftung Zurich and Central Switzerland Cancer League
This report describes the quasi-simultaneous occurrence of colon cancers in monozygotic twin brothers (age 63 years) who had undergone androgen deprivation therapy for prostate cancers 4 years earlier. Concordance among male twins for both of these cancers has never been reported. Although the family history suggested possible genetic predispositions to both cancers, the twins have no evidence of the genetic alterations associated with hereditary colorectal tumors. We explore the possibility that colorectal tumorigenesis in these twins was fuelled by a combination of genetic and iatrogenic factors, in particular the androgen deprivation therapy used to treat their prostate cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据