期刊
EYE
卷 29, 期 3, 页码 301-312出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/eye.2014.263
关键词
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资金
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research and Development's Career Development Award [CDA-2-024-10S]
- NIH Center Core Grant [P30EY014801]
- Research to Prevent Blindness Unrestricted Grant
- Department of Defense (DOD) [W81XWH-09-1-0675]
- NIH NIDCR [R01 DE022903]
- NATIONAL EYE INSTITUTE [P30EY014801] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE022903] Funding Source: NIH RePORTER
- Veterans Affairs [I01CX001089] Funding Source: NIH RePORTER
Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eye-associated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.
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