期刊
EYE
卷 28, 期 2, 页码 189-195出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/eye.2013.278
关键词
keratoconus; cornea; molecular genetics
资金
- Lanvern Foundation
- Moorfields Special Trustees
- Moorfields Eye Charity
- National Institute for Health Research (NIHR) (Moorfields Eye Hospital)
- National Institute for Health Research (NIHR) UCL Institute of Ophthalmology (London, UK)
- Rosetrees Trust
- Medical Research Council [MR/K000837/1] Funding Source: researchfish
- Rosetrees Trust [M311] Funding Source: researchfish
- MRC [MR/K000837/1] Funding Source: UKRI
Keratoconus (KC) is a common degenerative condition that frequently results in visual loss with an onset typically in early adulthood. It is the single most common reason for keratoplasty in the developed world. The cause and underlying pathological mechanism are unknown, but both environmental and genetic factors are thought to contribute to the development of the disease. Various strategies have been employed to address the gap in our understanding of this complex disease, with the expectation that over time more sophisticated therapies will be developed. In this review we summarise our current knowledge of the aetiology and risk factors associated with KC.
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