期刊
EYE
卷 26, 期 9, 页码 1188-1193出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/eye.2012.110
关键词
glaucoma; OCT; ganglion cell layer; inner plexiform layer
资金
- NIH/NEI [RO1-EY02115]
- CAPES BEX [4181/08-5]
Purpose To better understand the effects of severe glaucoma on the thickness of the retinal ganglion cell (RGC) and inner plexiform (IP) layers measured with frequency-domain optical coherence tomography. Methods In experiment 1, macular cube scans were obtained in 11 patients with glaucoma and the thickness of both the RGC and IP layers were measured at locations corresponding to 3, 5, and 7 degrees eccentricity. For patients, only locations with total deviation losses of -15 dB or worse on perimetry were included. In experiment 2, higher resolution, horizontal midline scans were obtained from 30 controls in order to obtain a precise measure of the thickness of the RGC and IP layers of the healthy retina. Results In regions of severe field loss (experiment 1), glaucoma decreased the thickness of both layers, leaving a residual layer. The residual thickness of the IP layer was larger than the residual thickness of the RGC layer. In healthy controls (experiment 2), the RGC layer was about 57% of the RGC+IP layer thickness at 3 degrees as compared with only 36% at 10 degrees, in agreement with a recent histological study. Conclusion Glaucomatous optic neuropathy, with severe losses in visual field sensitivity, decreases the thickness of both the RGC and IP layers, but leaves a residual thickness of both. The IP layer contributes slightly more than the RGC to this residual, even just outside the center of the fovea where the RGC layer thickness exceeds the IP layer thickness in controls. Eye (2012) 26, 1188-1193; doi:10.1038/eye.2012.110; published online 15 June 2012
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据