期刊
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
卷 30, 期 4, 页码 655-658出版社
WILEY-BLACKWELL
DOI: 10.1111/jdv.13100
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- Ministry of Instruction, University and Research of the Italian Government
- Dept. of Planning Marshalling and Economic Deals
- Regione Piemonte-Progetto per la Ricerca Sanitaria Finalizzata
BackgroundNo data are available as to the phenotype of circulating lymphocyte subsets in pyoderma gangrenosum (PG). AimTo analyse the expression of different chemokine receptors associated to T-helper (Th)1 (CCR5), Th2 (CCR4) and Th17 (CCR6), as well as the regulatory T-cell subset (Treg) and dendritic cell polarization in the blood of newly diagnosed untreated PG patients. Materials and methodsMulti-parameter flow cytometry was performed on blood samples from 10 PG patients collected at first diagnosis among centres belonging to the Italian Immuno-pathology Group. Blood samples from 10 age- and sex-matched healthy controls (HC) were used as controls. ResultsPG patients are characterized by an over-expression in the blood of the CD4+CCR5+ and CD4+CCR6+ and a down-regulation of CD4+CCR4+ counts with respect to healthy subjects. Moreover, they show increased levels of myeloid derived dendritic cells type1 and reduced levels of the Treg CD4+CD25highFOXP3+ subset. ConclusionsThe pattern of chemokine expression argues in favour of a Th1 (CCR5+) and Th17 (CCR6+) polarization with a down-regulation of Th2 (CCR4+).
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