期刊
EXPERT REVIEWS IN MOLECULAR MEDICINE
卷 12, 期 -, 页码 -出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1462399410001420
关键词
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资金
- Carlsberg Foundation
- Lundbeck Foundation
- German Mukoviszidose e.v.
- Danish Strategical Research Council
Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.
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