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Antitumor effect of F-PBF beta-TrCP-induced targeted PTTG1 degradation in HeLa cells
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Histone acetyltransferase p300 regulates the expression of human pituitary tumor transforming gene (hPTTG)
Tian Li et al.
JOURNAL OF GENETICS AND GENOMICS (2009)
Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer
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JOURNAL OF MOLECULAR ENDOCRINOLOGY (2009)
Transcriptional targets for pituitary tumor-transforming gene-1
Yunguang Tong et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2009)
E2F1 Induces Pituitary Tumor Transforming Gene (PTTG1) Expression in Human Pituitary Tumors
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Methylation alterations are not a major cause of PTTG1 missregulation
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Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer
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Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma
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CANCER RESEARCH (2008)
Thyroid hormone receptors suppress pituitary tumor transforming gene 1 activity in hepatoma
Ruey-Nan Chen et al.
CANCER RESEARCH (2008)
Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors
Cuiqi Zhou et al.
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UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase
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JOURNAL OF CELL SCIENCE (2008)
Structural and Dynamic Characterization of Intrinsically Disordered Human Securin by NMR Spectroscopy
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Securin regulates entry into M-phase by modulating the stability of cyclin B
Petros Marangos et al.
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Pituitary tumor transforming gene 1 regulates Aurora kinase A activity
Y. Tong et al.
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p21CiP1 restrains pituitary tumor growth
Vera Chesnokova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Proliferative potential after DNA damage and non-homologous end joining are affected by loss of securin
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CELL DEATH AND DIFFERENTIATION (2008)
Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth
Vera Chesnokova et al.
CANCER RESEARCH (2007)
Aberrant activation of γ-catenin promotes genomic instability and oncogenic effects during tumor progression
Hongjie Pan et al.
CANCER BIOLOGY & THERAPY (2007)
A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors
Anne Wierinckx et al.
ENDOCRINE-RELATED CANCER (2007)
Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition
Y. Tong et al.
ONCOGENE (2007)
Development of cystic glandular hyperplasia of the endometrium in Mullerian inhibitory substance type II receptor-pituitary tumor transforming gene transgenic mice
Shahenda M. El-Naggar et al.
JOURNAL OF ENDOCRINOLOGY (2007)
PTTG and PBF repress the human sodium iodide symporter
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ONCOGENE (2007)
Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility
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CARCINOGENESIS (2007)
The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer
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PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines
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Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity
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TGFβ inducible early gene-1 (TIEG1) and cardiac hypertrophy:: Discovery and characterization of a novel signaling pathway
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JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells
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MOLECULAR ENDOCRINOLOGY (2006)
Regulation of angiogenesis and invasion by human pituitary tumor transforming gene (PTTG) through increased expression and secretion of matrix metalloproteinase-2 (MMP-2)
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MOLECULAR CANCER (2006)
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression
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JOURNAL OF CLINICAL INVESTIGATION (2006)
Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study
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CLINICAL ENDOCRINOLOGY (2006)
Pituitary tumor transforming gene overexpression facilitates pituitary tumor development
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Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma
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Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction
Andrew J. Holland et al.
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PTTG overexpression is correlated with angiogenesis in human pituitary adenomas
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Overexpression of pituitary tumor transforming gene 1 in HCC is associated with angiogenesis and poor prognosis
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Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo
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Prognostic significance of human pituitary tumor-transforming gene immunohistochemical expression in differentiated thyroid cancer
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
Combination of multiple mRNA markers (PTTG1, survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array
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Human full-length Securin is a natively unfolded protein
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Securin is not required for chromosomal stability in human cells
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Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells
XX Huang et al.
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Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis
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Pituitary tumour transforming gene (PTTG) induces genetic instability in thyroid cells
D Kim et al.
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Pituitary tumor transforming gene binding factor: A novel transforming gene in thyroid tumorigenesis
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Securin is overexpressed in breast cancer
S Ogbagabriel et al.
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Mutual inhibition of separase and Cdk1 by two-step complex formation
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MOLECULAR CELL (2005)
Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells
AD Thompson et al.
FEBS LETTERS (2005)
Expression and functional analysis of pituitary tumor transforming growth factor-1 in uterine leiomyomas
SJ Tsai et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Regulation of the pituitary tumor transforming gene by insulin-like-growth factor-I and insulin differs between malignant and non-neoplastic astrocytes
K Chamaon et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Early multipotential pituitary focal hyperplasia in the α-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice
RA Abbud et al.
MOLECULAR ENDOCRINOLOGY (2005)
Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by β-catenin/TCF pathway in human esophageal squamous cell carcinoma
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Ectopic expression of PTTGI/securin promotes tumorigenesis in human embryonic kidney cells
Tariq Hamid et al.
MOLECULAR CANCER (2005)
Securin is a target of the UV response pathway in mammalian cells
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MOLECULAR AND CELLULAR BIOLOGY (2004)
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PTTG/securin activates expression of p53 and modulates its function
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GENE (2003)
Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression
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MOLECULAR ENDOCRINOLOGY (2003)
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CLINICAL ENDOCRINOLOGY (2003)
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CLINICAL ENDOCRINOLOGY (2003)
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DNA damage-induced inhibition of securin expression is mediated by p53
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
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Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells
R Yu et al.
ENDOCRINOLOGY (2003)
Human pituitary tumor transforming gene (hPTTG) inhibits human lung cancer A549 cell growth through activation of p21(WAF1)/CIP1
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Expression of hpttg proto-oneogene in lymphoid neoplasias
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ONCOGENE (2002)
Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis
JA Bernal et al.
NATURE GENETICS (2002)
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SCIENCE (2002)
Expression of PTTG (pituitary tumor transforming gene) in esophageal cancer
Y Shibata et al.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2002)
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
A Hagting et al.
JOURNAL OF CELL BIOLOGY (2002)
The dissociation of cohesin from chromosomes in prophase is regulated by polo-like kinase
I Sumara et al.
MOLECULAR CELL (2002)
Dual inhibition of sister chromatid separation at metaphase
O Stemmann et al.
CELL (2001)
Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division
ZY Wang et al.
MOLECULAR ENDOCRINOLOGY (2001)
Strain difference in regulation of pituitary tumor transforming gene (PTTG) in estrogen-induced pituitary tumorigenesis in rats
H Yin et al.
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AP Heaney et al.
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Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts
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CURRENT BIOLOGY (2001)
Securin is required for chromosomal stability in human cells
PV Jallepalli et al.
CELL (2001)
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L Pei
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase
F Romero et al.
NUCLEIC ACIDS RESEARCH (2001)
Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis
A Zur et al.
EMBO JOURNAL (2001)
Molecular cloning of pituitary tumor transforming gene 1 from ovarian tumors and its expression in tumors
R Puri et al.
CANCER LETTERS (2001)
Human pituitary tumor-transforming gene induces angiogenesis
H Ishikawa et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2001)
Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis
R Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase
IC Waizenegger et al.
CELL (2000)
Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: Evidence from live cell imaging
R Yu et al.
MOLECULAR ENDOCRINOLOGY (2000)
A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product
WW Chien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization
LL Chen et al.
GENE (2000)
Pituitary tumor transforming gene (PTTG) transforming and transactivation activity
ZY Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Expression of pituitary-tumour transforming gene in colorectal tumours
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LANCET (2000)
Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter
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ENDOCRINOLOGY (2000)
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
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