期刊
EXPERT REVIEW OF VACCINES
卷 14, 期 3, 页码 447-459出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2015.966085
关键词
Adaptive immunity; adjuvant; ampligen; hiltonol; innate immunity; interferons; PAMP; poly-IC; poly-ICLC; TLR3; vaccine
类别
资金
- Department of Defense, DTRA/JSTO
Pathogen-associated molecular patterns (PAMPs) are stand-alone immunomodulators or danger signals,' that are increasingly recognized as critical components of many modern vaccines. Polyinosinic-polycytidylic acid (poly-IC) is a synthetic dsRNA that can activate multiple elements of the host defense in a pattern that parallels that of a viral infection. When properly combined with an antigen, it can be utilized as a PAMP-adjuvant, resulting in modulation and optimization of the antigen-specific immune response. We briefly review the preclinical and clinical uses of poly-IC and two poly-IC derivatives, poly-IC12U (Ampligen) and poly-ICLC (Hiltonol), as vaccine adjuvants.
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