期刊
EXPERT REVIEW OF VACCINES
卷 13, 期 3, 页码 321-331出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14760584.2014.872035
关键词
Ascaris lumbricoides; Ascaris suum; deworming; geohelminth; hookworm; intestinal helminth; Necator americanus; Pan-anthelmintic vaccine; soil-transmitted helminth; soil-transmitted nematode; Trichinella spiralis; Trichuris muris; Trichuris trichiura
类别
资金
- Bill & Melinda Gates Foundation, Dutch Ministry of Foreign Affairs, and European Union FP-7 Program via Sabin Vaccine Institute and from the Brazilian Ministry of Health
The Sabin Vaccine Institute Product Development Partnership is developing a Pan-anthelmintic vaccine that simultaneously targets the major soil-transmitted nematode infections, in other words, ascariasis, trichuriasis and hookworm infection. The approach builds off the current bivalent Human Hookworm Vaccine now in clinical development and would ultimately add both a larval Ascaris lumbricoides antigen and an adult-stage Trichuris trichiura antigen from the parasite stichosome. Each selected antigen would partially reproduce the protective immunity afforded by UV-attenuated Ascaris eggs and Trichuris stichosome extracts, respectively. Final antigen selection will apply a ranking system that includes the evaluation of expression yields and solubility, feasibility of process development and the absence of circulating antigen-specific IgE among populations living in helminth-endemic regions. Here we describe a five year roadmap for the antigen discovery, feasibility and antigen selection, which will ultimately lead to the scale-up expression, process development, manufacture, good laboratory practices toxicology and preclinical evaluation, ultimately leading to Phase 1 clinical testing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据