期刊
EXPERT REVIEW OF VACCINES
卷 12, 期 6, 页码 687-702出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.13.48
关键词
epidermal powder immunization; immunogenicity; intradermal injection; microparticles; needle-free
类别
资金
- Novartis Vaccines
- GlaxoSmithKline
- Sanofi-Aventis
- Sanofi-Pasteur MSD
- Pfizer Vaccines
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Wellcome Trust
The central importance for global public health policy of delivering life-saving vaccines for all children makes the development of efficacious and safe needle-free alternatives to hypodermic needles, preferably in a thermostable form, a matter of pressing urgency. This paper comprehensively reviews past in vivo studies on intradermal powder immunization with vaccine formulations that do not require refrigeration. Particular emphasis is given to the immune response in relation to antigen adjuvantation. While needle-free intradermal delivery of vaccines induces a predominantly Th2-type immune response, adjuvants powerfully enhance and modulate the magnitude and nature of the elicited immune response at various effector sites.
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