期刊
EXPERT REVIEW OF VACCINES
卷 11, 期 7, 页码 841-855出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.12.53
关键词
herd immunity; invasive pneumococcal disease; pneumococcal carriage; pneumococcal colonization; pneumococcal vaccine licensure; pneumococcal vaccines; pneumococcus; vaccine effect on colonization
类别
资金
- Bill & Melinda Gates Foundation through the Grand Challenges in Global Health Initiative
- Berna/Crucell
- Wyeth/Pfizer
- MSD
- Protea
- Pfizer
- Merck
- Novartis
- Sanofi-Pasteur
- GSK
- National Institute for Health Research [NF-SI-0611-10066] Funding Source: researchfish
Streptococcus pneumoniae (pneumococcus) is a major cause of worldwide mortality and morbidity, and to a large extent is vaccine-preventable. Nasopharyngeal carriage of pneumococcus precedes disease and is the source of pneumococcal spread between people. The use of vaccine effect on carriage as part of the vaccine licensure and post-vaccine introduction evaluation could facilitate and expand the licensure of new, life-saving pneumococcal vaccines and enable a comprehensive estimate of population effects after vaccine introduction. The authors provide a review of the evidence supporting pneumococcal carriage at the individual level as an immediate and necessary precursor to pneumococcal disease. Based on such a causal link between carriage and disease, the authors emphasize the role of information on pneumococcal carriage in vaccine trials and in public health decision-making.
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