期刊
EXPERT REVIEW OF VACCINES
卷 10, 期 1, 页码 63-77出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.10.152
关键词
Ebola virus; filovirus; Marburg virus; postexposure; prophylactic; vaccine
类别
资金
- Division of Intramural Research, National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH)
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI001163, ZIAAI001089] Funding Source: NIH RePORTER
Marburg and Ebola viruses cause severe hemorrhagic fever in humans and nonhuman primates. Currently, there are no effective treatments and no licensed vaccines; although a number of vaccine platforms have proven successful in animal models. The ideal filovirus vaccine candidate should be able to provide rapid protection following a single immunization, have the potential to work postexposure and be cross-reactive or multivalent against all Marburg virus strains and all relevant Ebola virus species and strains. Currently, there are multiple platforms that have provided prophylactic protection in nonhuman primates, including DNA, recombinant adenovirus serotype 5, recombinant human parainfluenza virus 3 and virus-like particles. In addition, a single platform, recombinant vesicular stomatitis virus, has demonstrated both prophylactic and postexposure protection in nonhuman primates. These results demonstrate that achieving a vaccine that is protective against filoviruses is possible; the challenge now is to prove its safety and efficacy in order to obtain a vaccine that is ready for human use.
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