期刊
EXPERT REVIEW OF VACCINES
卷 10, 期 6, 页码 733-742出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERV.11.20
关键词
bladder cancer; cancer immunotherapy; cancer vaccines; CDX-1307; hCG-beta; human chorionic gonadotropin-beta chain
类别
Cancer vaccines have demonstrated clinical benefit, however greater efficacy could be achieved by enhancing their immunogenicity. Owing to cancer vaccines depending on uptake and cross-presentation of tumor antigens by antigen-presenting cells (APCs), we hypothesized that greater immunogenicity would accompany strategies that direct antigen to APC-expressed mannose receptors, initiating a pathway increasing class land II presentation to T cells. CDX-1307 consists of a human monoclonal antibody targeting the mannose receptor, fused to the human chorionic gonadotropin-beta chain (hCG-beta), a tumor antigen frequently expressed by epithelial cancers including bladder cancer. In Phase I studies of cancer patients, CDX-1307 was well tolerated and induced significant hCG-beta-specific cellular and humoral immune responses when co-administered with GM-CSF and the Toll-like receptor agonists resiquimod and poly-ICLC. An ongoing Phase II trial evaluates CDX-1307 in patients with newly diagnosed, resectable, hCG-beta-expressing bladder cancer, where low tumor burden and early intervention may provide greater potential for benefit.
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