期刊
EXPERT REVIEW OF PROTEOMICS
卷 15, 期 10, 页码 801-808出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14789450.2018.1528149
关键词
Biomarkers; cancer; extracellular vesicles; mass spectrometry; microvesicles; precision medicine
资金
- Cinque per mille e Ricerca Corrente, Ministero della Salute
- Compagnia di San Paolo [2016.AAI1017.U1260/2015.0408/1039]
- Renal Child Foundation
Introduction: Shed by most cells, in response to a myriad of stimuli, extracellular vesicles (EVs) carry proteins, lipids, and various nucleic acids. EVs encompass diverse subpopulations differing for biogenesis and content. Among these, microvesicles (MVs) derived from plasma membrane, are key regulators of physiopathological cellular processes including cancer, inflammation and infection. This review is unique in that it focuses specifically on the MVs as a mediator of information transfer. In fact, few proteomic studies have rigorously distinguished MVs from exosomes. Areas covered: Aim of this review is to discuss the proteomic analyses of the MVs. Many studies have examined mixed populations containing both exosomes and MVs. We discuss MVs' role in cell-specific interactions. We also show their emerging roles in therapy and diagnosis. Expert commentary: We see MVs as therapeutic tools for potential use in precision medicine. They may also have potential for allowing the identification of new biomarkers. MVs represent an invaluable tool for studying the cell of origin, which they closely represent, but it is critical to build a repository with data from MVs to deepen our understanding of their molecular repertoire and biological functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据