期刊
EXPERT REVIEW OF PROTEOMICS
卷 10, 期 6, 页码 511-520出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.2013.856764
关键词
3D protein-protein interaction networks; disease-causing mutations; drug design; nsSNPs; protein complexes interface regions; protein-protein interaction networks
资金
- King's College London (London, UK)
- British Heart Foundation
Protein-protein interaction networks (PPINs) are a powerful tool to study biological processes in living cells. In this review, we present the progress of PPIN studies from abstract to more detailed representations. We will focus on 3D interactome networks, which offer detailed information at the atomic level. This information can be exploited in understanding not only the underlying cellular mechanisms, but also how human variants and disease-causing mutations affect protein functions and complexes' stability. Recent studies have used structural information on PPINs to also understand the molecular mechanisms of binding partner selection. We will address the challenges in generating 3D PPINs due to the restricted number of solved protein structures. Finally, some of the current use of 3D PPINs will be discussed, highlighting their contribution to the studies in genotype-phenotype relationships and in the optimization of targeted studies to design novel chemical compounds for medical treatments.
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