期刊
EXPERT REVIEW OF PROTEOMICS
卷 7, 期 5, 页码 647-653出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/EPR.10.29
关键词
IPTL; isobaric peptide termini labeling; isobaric tag for relative and absolute quantification; isobaric tagging; iTRAQ; multiplexing; quantitative proteomics; tandem mass tagging; TMT
资金
- Norwegian Research Council [183418/S10]
An important challenge for proteomics is the ability to compare protein levels across biological samples. Since their introduction, isotopic and isobaric peptide labeling have played an important role in relative quantitative comparisons of proteomes. One important drawback of most of the isotopic-labeling techniques is an increase in sample complexity. This problem was successfully addressed with the construction of isobaric labeling strategies, such as isobaric tag for relative and absolute quantification (iTRAQ), tandem mass tagging, the cleavable isobaric affinity tag, dimethylated leucines and isobaric peptide termini labeling. Furthermore, numerous applications for multiplexing using iTRAQ and tandem mass tagging have been reported.
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