期刊
EXPERT REVIEW OF PROTEOMICS
卷 7, 期 2, 页码 227-237出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/EPR.09.106
关键词
formalin-fixed; paraffin-embedded tissue; high throughput; multiplex protein analysis; protein array; protein extraction; proteomic profiling; radiographic-histopathologic correlation; tissue immunoblotting; tissue microarray
资金
- Intramural NIH HHS [ZIC BC010923] Funding Source: Medline
In the functional proteome era, the proteomic profiling of clinicopathologic-annotated tissues is an essential step for mining and evaluating candidate biomarkers for disease. For many diseases, but especially cancer, the development of predictive biomarkers requires performing assays directly on the diseased tissue. The last decade has seen the explosion of both prognostic and predictive biomarkers in the research setting but few of these biomarkers have entered widespread clinical use. Previously, application of routine proteomic methodologies to clinical formalin-fixed and paraffin-embedded tissue specimens has provided unsatisfactory results. In this paper, we will discuss recent advancements in proteomic profiling technology for clinical applications. These approaches focus on the retention of histomorphologic information as an element of the proteomic analysis.
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