期刊
EXPERT REVIEW OF PROTEOMICS
卷 7, 期 1, 页码 79-92出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/EPR.09.100
关键词
electron-capture dissociation; electron-transfer dissociation; histone code; mass spectrometry; middle-down approach; post-translational modification; proteomics; top-down approach
资金
- Waters Corporation
- New Jersey Commission on Cancer Research SEED
- Princeton University
- National Science Foundation [CBET-0941143]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0941143] Funding Source: National Science Foundation
Protein post-translational modifications (PTMs) have been widely shown to influence protein-protein interactions, direct subcellular location and transduce a variety of both internal and externally generated signals into cellular/phenotypic outcomes. Mass spectrometry has been a key tool for the elucidation of several types of PTMs in both qualitative and quantitative manners. As large datasets on the proteome-wide level are now being generated on a daily basis, the identification of combinatorial PTM patterns has become feasible. A survey of the recent literature in this area shows that many proteins undergo multiple modifications and that sequential or hierarchal patterns exist on many proteins; the biology of these modification patterns is only starting to be unraveled. This review will outline combinatorial PTM examples in biology, and the mass spectrometry-based techniques and applications utilized in the investigations of these combinatorial PTMs.
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