期刊
EXPERT REVIEW OF PROTEOMICS
卷 6, 期 3, 页码 243-249出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/EPR.09.46
关键词
brain mapping; in situ hybridization; mass spectrometry; microarray; mouse model; neurodegeneration; Parkinson's disease; proteomics; transcriptomic; voxelation
资金
- NCRR NIH HHS [P41 RR018522-06, P41 RR018522-055018, P41 RR018522, RR18522] Funding Source: Medline
- NINDS NIH HHS [R01 NS050148-04, R01 NS050148] Funding Source: Medline
Integrating quantitative proteomic and transcriptomic datasets promises valuable insights in unraveling the molecular mechanisms of the brain. We concentrate on recent studies using mass spectrometry and microarray data to investigate transcript and protein abundance in normal and diseased neural tissues. Highlighted are dual spatial maps of these molecules obtained using voxelation of the mouse brain. We demonstrate that the relationship between transcript and protein levels displays a specific anatomical distribution, with greatest fidelity in midline structures and the hypothalamus. Genes are also identified that have strong correlations between mRNA and protein abundance. In addition, transcriptomic and proteomic analysis of mouse models of Parkinson's disease are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据