期刊
EXPERT REVIEW OF PROTEOMICS
卷 5, 期 4, 页码 619-627出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.5.4.619
关键词
bacterial pathogen; cellular adhesion; gene regulation; kinase; mass spectrometry; phosphatase; phosphoproteomics; protein phosphorylation; signaling; virulence
资金
- Danish Natural Science Research Council (FNU)
- Agence Nationale de la Recherche (ANR-07-JCJC0125-01)
Bacteria use protein phosphorylation to regulate all kinds of physiological processes. Protein phosphorylation plays a role in several key steps of the infection process of bacterial pathogens, such as adhesion to the host, triggering and regulation of pathogenic functions as well as biochemical warfare; scrambling the host signaling cascades and impairing its defense mechanisms. Recent phosphoproteomic studies indicate that the bacterial protein phosphorylation networks could be more complex than initially expected, comprising promiscuous kinases that regulate several distinct cellular functions by phosphorylating different protein substrates. Recent advances in protein labeling with stable isotopes in the field of quantitative mass spectrometry phosphoproteomics will enable us to chart the global phosphorylation networks and to understand the implication of protein phosphorylation in cellular regulation on the systems scale. For the study of bacterial pathogens, in particular, this research avenue will enable us to dissect phosphorylation-related events during different stages of infection and stimulate our efforts to find inhibitors for key kinases and phosphatases implicated therein.
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