期刊
EXPERT REVIEW OF PROTEOMICS
卷 5, 期 5, 页码 679-691出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.5.5.679
关键词
atherosclerosis; biomarker validation; cardiovascular biomarker; cardiovascular disease; imaging mass spectrometry; vascular proteomics
资金
- Ministerio de Ciencia [BFU-2005-08838]
- CAM [S2006/GEN-0247]
- Mutua Madrilena Automovilista and FINA-Biotech [FIS PI070537]
- Ministerio de Educacion y Ciencia [JCI-2006-3349]
Vascular proteomics is providing two main types of data: proteins that actively participate in vascular pathophysiological processes and novel protein candidates that can potentially serve as useful clinical biomarkers. Although both types of proteins can be identified by similar proteomic strategies and methods, it is important to clearly distinguish biomarkers from mediators of disease. A particular protein, or group of proteins, may participate in a pathogenic process but not serve as an effective biomarker. Alternatively, a useful biomarker may not mediate pathogenic pathways associated with disease (i.e., C-reactive protein). To date, there are no clear successful examples in which discovery proteomics has led to a novel useful clinical biomarker in cardiovascular diseases. Nevertheless, new sources of biomarkers are being explored (i.e., secretomes, circulating cells, exosomes and microparticles), an increasing number of novel proteins involved in atherogenesis are constantly described, and new technologies and analytical strategies (i.e., quantitative proteomics) are being developed to access low abundant proteins. Therefore, this presages a new era of discovery and a further step in the practical application to diagnosis, prognosis and early action by medical treatment of cardiovascular diseases.
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