期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 12, 期 7, 页码 871-884出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.12.66
关键词
chromatin; genomics; medulloblastoma; molecular classification; pediatric brain tumors; subgroups
资金
- NIH [CA159859]
Recent efforts at stratifying medulloblastomas based on their molecular features have revolutionized our understanding of this morbidity. Collective efforts by multiple independent groups have subdivided medulloblastoma from a single disease into four distinct molecular subgroups characterized by disparate transcriptional signatures, mutational spectra, copy number profiles and, most importantly, clinical features. We present a summary of recent studies that have contributed to our understanding of the core medulloblastoma subgroups, focusing largely on clinically relevant discoveries that have already, and will continue to, shape research.
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