期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 12, 期 6, 页码 673-686出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.12.47
关键词
alpha-synuclein; Braak staging for PD; clinicopathological correlations; Lewy bodies; Lewy neurites; neuropathology; Parkinson's disease
资金
- National Health & Medical Research Council of Australia
- NHMRC [510148, 570850, 1008307, 1022325, 1029538]
- ARC [LE100100074, 401162]
- University of New South Wales
- Goldstar award
- Parkinson's NSW
- Michael J Fox Foundation
- Shake-it-up Australia
Braak's proposal that, in patients with Parkinson's disease, Lewy bodies and neurites progressively invade the brain through regions connected to autonomic and olfactory centers remains contentious. Confounding factors include the lack of an in vivo marker to examine the progression of Lewy pathology, the retrospective nature or absence of clinical information for many cross-sectional pathological datasets, and for those with limited disease (clinically or neuropathologically), the absence of information concerning additional conditions. Despite these data limitations at this time, the brain pathology for most patients with typical Parkinson's disease can be predicted using Braak's scheme. What this tells us about the pathogenesis of Parkinson's disease will be explored in this review.
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