期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 11, 期 7, 页码 951-959出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.11.78
关键词
adjunct therapy; estrogen; schizophrenia; sex differences; sex steroid hormones; testosterone
资金
- Canadian Institutes of Health Research (CIHR Institute of Gender and Health)
- Fonds de recherche en sante Quebec (FRSQ)
- Louis-H Lafontaine Hospital Research Foundation
Gender differences have been reported in various aspects of schizophrenia, including its epidemiology, clinical course and the response to antipsychotic medications. Over the past few years the authors have been investigating sex differences in brain function in individuals with schizophrenia and have found an intriguing disturbance of normal sexual dimorphism during emotional and cognitive processing. These results can be partly accounted for by altered levels of sex steroid hormones (i.e., estrogen and testosterone) in patients. A handful of clinical research groups have tried low doses of estrogen, testosterone or their precursors as adjunct therapies to the currently available antipsychotic medications in women and men with schizophrenia. The results have been promising, but further investigation is warranted. In the future, new more specific steroidal compounds will be developed and we will see more studies examining sex differences in the brain, behavior and mental health problems. This research will help to identify individuals who may benefit greatest from adjunct hormonal therapies and will further our understanding of the etiology of schizophrenia and other psychiatric disorders.
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