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Giselle Y. Lopez et al.
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Elaine R. Mardis et al.
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Hai Yan et al.
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Sin Young Park et al.
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In Sup Kil et al.
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Jin Hyup Lee et al.
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S Lee et al.
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HJ Koh et al.
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SH Lee et al.
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I Shechter et al.
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