期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 10, 期 11, 页码 1675-1688出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERN.10.162
关键词
amyloid; biomarker; CSF; mild cognitive impairment; prodromal Alzheimer's disease; quantitative neuroimaging; volumetric imaging
资金
- NIA [K0IAG029218]
- NINDS [K02 NS067427]
- Janssen Alzheimer Immunotherapy
- GE medical foundation
Alzheimer's disease (AD) is a common progressive neurodegenerative disorder that is not currently diagnosed until a patient reaches the stage of dementia. There is a pressing need to identify AD at an earlier stage, so that treatment, when available, can begin early. Quantitative structural MRI is sensitive to the neurodegeneration that occurs in mild and preclinical AD, and is predictive of decline to dementia in individuals with mild cognitive impairment. Objective evidence of ongoing brain atrophy will be critical for risk/benefit decisions once potentially aggressive, disease-modifying treatments become available. Recent advances have paved the way for the use of quantitative structural MRI in clinical practice, and initial clinical use has been promising. However, further experience with these measures in the relatively unselected patient populations seen in clinical practice is needed to complete translation of the recent enormous advances in scientific knowledge of AD into the clinical realm.
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