期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 11, 期 1, 页码 91-100出版社
TAYLOR & FRANCIS AS
DOI: 10.1586/ERM.10.97
关键词
alternative activation; breast cancer; leukocyte infiltrate; tumor-associated macrophage
类别
资金
- California Breast Cancer Research Program [15FB-0108]
While several inflammatory cell types participate in cancer development, macrophages specifically play a key role in breast cancer, where they appear to be part of the pathogenesis of high-grade tumors. Tumor-associated macrophages (TAMs) produce factors that promote angiogenesis, remodel tissue and dampen the immune response to tumors. Specific macrophage types contribute to increased metastases in animal models, while human studies show an association between TAMs and tumors with poor prognostic features. Macrophages display a spectrum of phenotypic states, with the tumor microenvironment skewing TAMs towards a 'nonclassical' activation state, known as the M2, or wound healing/regulatory state. These TAMs are found in high-risk breast cancers, making them an important therapeutic target to explore. Improved techniques for identifying TAMs should translate into clinical applications for prognosis and treatment.
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