期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 11, 期 7, 页码 691-694出版社
EXPERT REVIEWS
DOI: 10.1586/ERM.11.57
关键词
cancer biomarker; colorectal cancer; CRC; feces; methylation; microRNA; miRNA; noninvasive colorectal cancer screening
类别
MicroRNAs regulate target gene expression through translation repression or mRNA decay, and they are emerging as important modulators in cellular pathways. Previous studies have shown the occurrence of epigenetically modified miRNAs in colorectal cancer (CRC), identifying these miRNA methylation signatures may provide candidate markers for the detection of malignant colonocytes. Fecal-based tests are widely adopted as noninvasive methods for CRC diagnosis, thus several studies have attempted to use miRNAs from feces as CRC markers. This article evaluates a recently published study investigating the usefulness of epigenetically silenced miRNAs in fecal specimens, including miR-34b/c and miR-148a, as potential markers for CRC screening and prognosis.
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