期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 10, 期 6, 页码 817-829出版社
TAYLOR & FRANCIS AS
DOI: 10.1586/ERM.10.59
关键词
3 ' UTR; cancer; miRNA; miRNA binding site; SNP
类别
资金
- NIH [K08 (CA 124484), R01 (CA131301-01A1)]
- NATIONAL CANCER INSTITUTE [R01CA131301, K08CA124484] Funding Source: NIH RePORTER
MicroRNAs (miRNAs) are well established as global gene regulators and thus, slight alterations in miRNA levels as well as their ability to regulate their targets may cause important cellular changes leading to cancer risk. 3' untranslated region (UTR) miRNA binding site single nucleotide polymorphisms (SNPs) have added another layer of possible genetic variation involved in the complex process of oncogenesis. Identifying these key genetically inherited effectors of miRNA functioning has improved our understanding of the complexity of disease. Interest in the field has grown rapidly in only the last 5 years, with several studies reporting on the role of 3'UTR binding site SNPs as genetic markers of increased cancer susceptibility, as well as biomarkers of cancer type, outcome and response to therapy. Currently, there are numerous known miRNA binding site SNPs associated with multiple cancer subtypes.
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