期刊
EXPERT REVIEW OF MEDICAL DEVICES
卷 9, 期 6, 页码 577-594出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERD.12.51
关键词
aortic stenosis; device thrombogenicity emulation; nano-composite; platelet activation; polyurethane; SIBS; transcatheter valve replacement
资金
- NIH-NIBIB (National Institute of Bioimaging and Bioengineering) via a Quantum Implementation Phase II award [1U01EB012487-0]
Present prosthetic heart valves, while hemodynamically effective, remain limited by progressive structural deterioration of tissue valves or the burden of chronic anticoagulation for mechanical valves. An idealized valve prosthesis would eliminate these limitations. Polymeric heart valves (PHVs), fabricated from advanced polymeric materials, offer the potential of durability and hemocompatibility. Unfortunately, the clinical realization of PHVs to date has been hampered by findings of in vivo calcification, degradation and thrombosis. Here, the authors review the evolution of PHVs, evaluate the state of the art of this technology and propose a pathway towards clinical reality. In particular, the authors discuss the development of a novel aortic PHV that may be deployed via transcatheter implantation, as well as its optimization via device thrombogenicity emulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据