期刊
EXPERT REVIEW OF MEDICAL DEVICES
卷 6, 期 4, 页码 401-410出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERD.09.23
关键词
closed-loop insulin delivery; continuous glucose monitor; control algorithm; diabetes; euglycemia; insulin pump; subcutaneous route
资金
- The Juvenile Diabetes Research Foundation
- National Institute for Health Research Biomedical Research Center
- Diabetes UK
- Diabetes UK [07/0003549] Funding Source: researchfish
- Medical Research Council [G0600717B] Funding Source: researchfish
Intensive insulin therapy aimed at achieving normal glucose levels significantly reduces the complications that are associated with diabetes but is also associated with an increased risk of low glucose levels (hypoglycemia). The growing use of continuous glucose monitors has stimulated the development of the artificial pancreas, a closed-loop insulin-delivery system aimed at restoring near-normal glucose levels while reducing the risk of hypoglycemia. The artificial pancreas comprises three components: a continuous glucose monitor, an insulin infusion pump and a control algorithm delivering insulin according to real-time glucose readings. In this article, we review closed-loop glucose control, including its components, development, testing and clinical application.
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