期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 10, 期 9, 页码 1165-1170出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2014.942289
关键词
adipokines; innate and adaptive immunity; leptin; macrophages; monocytes; T regulatory cell; Th1; Th2
类别
Until the discovery of leptin 20 years ago, adipose tissue was considered only as a fat storage organ, involved in the regulation of energy homeostasis. At present, it is well known that adipokines, being leptin the forerunner of this superfamily, may act in different biological processes, including inflammation and immunity. In this review, we have explored the recent evidence about the relationship between leptin and immune system, summarizing the most important findings related to the involvement of leptin in both innate and adaptive immune response.
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