期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 10, 期 6, 页码 729-739出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.2014.906302
关键词
antihistamines; brain; c-kit mutation; IgE; inflammation; mast cell; mastocytosis; mediators; tryptase
类别
资金
- US National Institutes of Health (NIH) [NS055681, DK062861, AR47652, NS66205, NS71361]
- Theta Biomedical Consulting and Development Co., Inc. (Brookline, MA, USA)
Mast cell (MC) activation disorders present with multiple symptoms including flushing, pruritus, hypotension, gastrointestinal complaints, irritability, headaches, concentration/memory loss and neuropsychiatric issues. These disorders are classified as: cutaneous and systemic mastocytosis with a c-kit mutation and clonal MC activation disorder, allergies, urticarias and inflammatory disorders and mast cell activation syndrome (MCAS), idiopathic urticaria and angioedema. MCs are activated by IgE, but also by cytokines, environmental, food, infectious, drug and stress triggers, leading to secretion of multiple mediators. The symptom profile and comorbidities associated with these disorders, such as chronic fatigue syndrome and fibromyalgia, are confusing. We propose the use of the term spectrum' and highlight the main symptoms, useful diagnostic tests and treatment approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据