期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 8, 期 1, 页码 55-62出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.11.76
关键词
HLA; Lofgren's syndrome; phenotype; sarcoidosis; T cells
类别
资金
- Swedish Heart-Lung Foundation
- King Oscar II Jubilee Foundation
- Swedish Medical Research Council
- Torsten and Ragnar Soderbergs Foundation
- Karolinska Institutet
Patients with sarcoidosis can be subgrouped according to organ engagement and clinical manifestations. One such subgroup is Lofgren's syndrome (LS), constituting a distinct group of sarcoidosis patients with typical clinical manifestations, separate genetic associations and an immune response that seems to differ from that of non-LS patients. In particular, LS patients have strong associations with HLA-DRB1 alleles, and the well-known association with HLA-DRB1*03 is particularly striking. This particular HLA-DRB1 allele is also a very strong marker within that particular group of patients for a prognostically favorable disease course. This article will mainly discuss genetic associations with LS, and the possible implications of such associations.
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