期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 8, 期 7, 页码 621-634出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.12.56
关键词
alpha 1,3-galactosyltransferase gene-knockout; hCD46; liver; liver failure; nonhuman primate; pig; xenotransplantation
类别
资金
- NIH NIAID [T32 AI 074490]
- NIH [U19 AI090959-01, 5R01DK066160-05]
- University of Pittsburgh
- Revivicor, Inc., Blacksburg, VA, USA
Expert Rev. Clin. Immunol. 8(7), 621-634 (2012) Pigs are currently the preferred species for future organ xenotransplantation. With advances in the development of genetically modified pigs, clinical xenotransplantation is becoming closer to reality. In preclinical studies (pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenic for human CD55 or from alpha 1,3-galactosyltransferase gene-knockout pigs+/- transgenic for human CD46, is associated with survival of approximately 7-9 days. Although hepatic function, including coagulation, has proved to be satisfactory, the immediate development of thrombocytopenia is very limiting for pig liver xenotransplantation even as a 'bridge' to allotransplantation. Current studies are directed to understand the immunobiology of platelet activation, aggregation and phagocytosis, in particular the interaction between platelets and liver sinusoidal endothelial cells, hepatocytes and Kupffer cells, toward identifying interventions that may enable clinical application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据