期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 8, 期 6, 页码 547-555出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.12.45
关键词
antigen presentation; CD141; CD8 alpha(+) DC; cross presentation; dendritic cells; immunotherapy; XCR1
类别
资金
- Clarendon Scholarship
- Keith Murray Scholarship
- Oxford Stem Cell Institute
- MRC [G0802538] Funding Source: UKRI
- Medical Research Council [G0802538] Funding Source: researchfish
Dendritic cells (DCs) possess the specialized potential to present exogenously derived antigen to cytotoxic T lymphocytes to elicit an immune response. This process, termed cross presentation, is crucial in the generation of immune response to viruses, tumors and in autoimmune disease. The ability of DCs to cross-present exogenous antigen to cytotoxic T lymphocytes makes them an attractive target for exploitation in immunotherapy. In recent years, significant advances have been made in understanding the mechanism of cross-presentation and the DC subsets involved. The recent discovery of the human cross presenting DC has given this field a new lease of life. In this report, the authors provide an overview of cross-presentation of antigen by DCs, focusing on the current understanding of the molecular mechanisms of the process. The authors also discuss the DC subsets involved in cross presentation and its role in health and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据