期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 7, 期 1, 页码 55-63出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/ECI.10.90
关键词
anaphylaxis; anti-TNF-alpha antibody; biological agents; drug allergy; infliximab; mAbs; monoclonal antibodies
类别
This article reports recent evidence on epidemiological data concerning monoclonal antibody (mAb) infusion-related anaphylaxis, as well as recent data on the correlation between mAb immunogenicity and safety profiles. Pathogenic mechanisms of mAb-related adverse reactions including hypersensitivity, IgE- and non-IgE-mediated events and cytokine release syndrome are also highlighted. Finally, the role of serum anti-mAb antibodies as markers to monitor the safety of such therapeutical compounds are extensively evaluated. The anaphylaxis occurring during therapy with the anti-TNF-alpha mAb infliximab, largely used in immune-mediated diseases, has been taken as a paradigm.
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