期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 5, 期 1, 页码 97-109出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/1744666X.5.1.97
关键词
airway inflammation; asthma; genetic variants; infection; innate immunity
类别
资金
- NHLBI NIH HHS [P01 HL073907, P01 HL073907-059001] Funding Source: Medline
- NIAID NIH HHS [R01 AI070175, R01 AI070175-01A2] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL073907] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI070175] Funding Source: NIH RePORTER
Genetic and environmental factors interact to initiate and even maintain the course of asthma. As one of the highly risky environmental factors, infections in predisposed individuals can promote asthma development and exacerbations and/or prolong symptoms. This review will describe our current understanding of the genetic markers of innate immunity in the induction and development of asthma, the diverse roles of infections in modulating allergic inflammation, host susceptibility to infections and subsequent acute exacerbations in an allergic setting, and the therapeutic or preventive implications of existing knowledge. Current challenges and future directions in basic and clinical research of asthma are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据