期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 5, 期 2, 页码 137-144出版社
EXPERT REVIEWS
DOI: 10.1586/1744666X.5.2.137
关键词
anterior chamber; anterior chamber-associated immune deviation; corneal transplantation; eye; immune privilege; natural killer T cell; tolerance; T regulatory cell
类别
资金
- NEI NIH HHS [R01 EY007641, R01 EY005631, R01 EY005631-24, R01 EY007641-21] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY007641, R01EY005631] Funding Source: NIH RePORTER
Cells in the eye have a limited capacity for regeneration and, as such, immune-mediated inflammation can lead to blindness. The eye is designed to quench immune-mediated inflammation - a condition known as immune privilege. An important component of immune privilege is the dynamic immunoregulatory process termed anterior chamber-associated immune deviation (ACAID), which is initiated when antigens enter the eye. ACAID suppresses the initiation of antigen-specific inflammation in the eye and the effector stages of immune reactions. Four organ systems are crucial for the induction of ACAID: the eye, thymus, spleen and sympathetic nervous system. Multiple cell populations contribute to ACAID, with natural killer T cells playing a crucial role in the thymic and splenic phases of ACAID. Interactions between natural killer T cells and multiple cell populations in the spleen culminate in the tight regulation of immune-mediated inflammation in the eye and the preservation of vision.
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