期刊
EXPERT REVIEW OF ANTICANCER THERAPY
卷 15, 期 2, 页码 157-164出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737140.2015.974563
关键词
brainstem tumor; chemotherapy; clinical trial; diffuse intrinsic pontine glioma; high-grade glioma; pediatric oncology; radiotherapy; treatment
类别
资金
- Semmy Foundation (Stichting Semmy)
- Egbers Foundation (Egbers Stichting)
- Children Cancer-free foundation (KiKa)
- VONK (VUmc research on Childhood Cancer)
Introduction: Children with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with a median overall survival of 9 months. Our aims are to determine the incidence of DIPG in the Netherlands and to identify points for improvement in clinical research, a prerequisite for increasing the chance to find a cure. Methods: We performed a population-based retrospective cohort study by evaluating all children diagnosed with DIPG in the Netherlands between 1990 and 2010. Results: The incidence of DIPG in the Netherlands corresponds with international literature. Between 1990 and 2010, a large heterogeneity of treatment schedules was applied and only a minority of patients was included in clinical trials. Discussion: Given the rarity of DIPG, we emphasize the need for (inter-)national trials to facilitate the identification of potentially effective therapeutics in the future. This can be supported by the recent development of a European DIPG registry enabling international study collaborations.
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